cb 839 Search Results


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Cayman Chemical cb-839, an inhibitor of glutaminase
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ApexBio cb839
Characterizations of CLCeMOF. (A) Schematic picture of cascade catalytic reactions in CLCeMOF to bring out “ROS” storm (B) TEM image of CeMOF. The ultra-small CeO 2 particles were evenly arranged on the MOFs frame. (C) TEM of LCeMOF (D) FT-IR spectra. (E) The drug release profile of <t>CB839</t> and CLCeMOF in PBS ( n = 3). (F) Lactate consumption after different treatments ( n = 3). ∗∗∗ P < 0.001 versus CeMOF group. (G) H 2 O 2 generation detection after incubating lactate with LOX ( n = 3). (H) XPS spectrum of CeMOF (I) ·OH generation followed by oxidization reaction of ABTS into ABTS ·+ . CeMOF with different concentrations was incubated with H 2 O 2 at pH 6 for 10 min. (J) ·OH generation detection after different treatments (K) GSH level detection in 4T1 cells ( n = 4). Data are presented as mean ± SD; ∗∗∗ P < 0.001.
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Image Search Results


Characterizations of CLCeMOF. (A) Schematic picture of cascade catalytic reactions in CLCeMOF to bring out “ROS” storm (B) TEM image of CeMOF. The ultra-small CeO 2 particles were evenly arranged on the MOFs frame. (C) TEM of LCeMOF (D) FT-IR spectra. (E) The drug release profile of CB839 and CLCeMOF in PBS ( n = 3). (F) Lactate consumption after different treatments ( n = 3). ∗∗∗ P < 0.001 versus CeMOF group. (G) H 2 O 2 generation detection after incubating lactate with LOX ( n = 3). (H) XPS spectrum of CeMOF (I) ·OH generation followed by oxidization reaction of ABTS into ABTS ·+ . CeMOF with different concentrations was incubated with H 2 O 2 at pH 6 for 10 min. (J) ·OH generation detection after different treatments (K) GSH level detection in 4T1 cells ( n = 4). Data are presented as mean ± SD; ∗∗∗ P < 0.001.

Journal: Acta Pharmaceutica Sinica. B

Article Title: A metabolic intervention strategy to break evolutionary adaptability of tumor for reinforced immunotherapy

doi: 10.1016/j.apsb.2022.10.021

Figure Lengend Snippet: Characterizations of CLCeMOF. (A) Schematic picture of cascade catalytic reactions in CLCeMOF to bring out “ROS” storm (B) TEM image of CeMOF. The ultra-small CeO 2 particles were evenly arranged on the MOFs frame. (C) TEM of LCeMOF (D) FT-IR spectra. (E) The drug release profile of CB839 and CLCeMOF in PBS ( n = 3). (F) Lactate consumption after different treatments ( n = 3). ∗∗∗ P < 0.001 versus CeMOF group. (G) H 2 O 2 generation detection after incubating lactate with LOX ( n = 3). (H) XPS spectrum of CeMOF (I) ·OH generation followed by oxidization reaction of ABTS into ABTS ·+ . CeMOF with different concentrations was incubated with H 2 O 2 at pH 6 for 10 min. (J) ·OH generation detection after different treatments (K) GSH level detection in 4T1 cells ( n = 4). Data are presented as mean ± SD; ∗∗∗ P < 0.001.

Article Snippet: CB839 was brought from APExBIO (Houston, TX, USA).

Techniques: Incubation